DNA Topoisomerase II: Enzyme Involved in DNA Replication and More

Target Name: DNA Topoisomerase II

NCBI ID: P6874

DNA Topoisomerase II

Other Name(s): None

DNA Topoisomerase II: Enzyme Involved in DNA Replication and More

DNA Topoisomerase II (nonspecified subtype) is an enzyme that plays a crucial role in the process of DNA replication in eukaryotic cells. It is a topoisomerase, which means it helps to unwind double-stranded DNA and create two complementary copies of the same strand. In addition to its role in DNA replication, DNA topoisomerase II is also involved in the regulation of gene expression and has been implicated in a number of cellular processes, including cell division, differentiation, and the response to environmental stimuli.

The DNA topoisomerase II is a protein that consists of 265 amino acids and has a molecular weight of 31 kDa. It has a single subunit and is composed of a catalytic domain and a nucleotide-binding domain. The catalytic domain is responsible for the substrate- dependent catalytic activity of the enzyme, while the nucleotide-binding domain is responsible for binding to DNA and participating in the DNA replication process.

DNA topoisomerase II has a unique structure that allows it to efficiently bind to DNA. The enzyme has a parallel beta-sheet structure, which is characterized by a central alpha-helices and a series of beta-strands that extend from the alpha-helices in each direction. The loops and arcs in the protein's beta-sheet provide a binding site for the nucleotides, allowing the enzyme to efficiently unwrap the double-stranded DNA and create two complementary copies.

DNA topoisomerase II has been shown to play a role in a number of cellular processes. For example, it has been shown to be involved in the regulation of gene expression in various organisms, including bacteria and yeast. In addition, DNA topoisomerase II has been shown to be involved in the process of DNA replication in eukaryotic cells, including the regulation of the timing of DNA replication and the ability to repair damaged DNA.

DNA topoisomerase II has also been shown to be involved in the regulation of DNA-protein interactions and in the role of DNA in cell signaling. For example, it has been shown to interact with the protein p21, which is a transcription factor that plays a role in cell proliferation and apoptosis. In addition, DNA topoisomerase II has been shown to interact with the protein p53, which is a tumor suppressor protein that plays a role in the regulation of DNA replication and repair.

DNA topoisomerase II has also been shown to be involved in a number of cellular processes that are important for cell survival and reproduction. For example, it has been shown to be involved in the regulation of cell division in various organisms, including bacteria and yeast. In addition, DNA topoisomerase II has been shown to be involved in the regulation of DNA replication in eukaryotic cells, including the regulation of the timing of DNA replication and the ability to repair damaged DNA.

In addition to its role in cellular processes, DNA topoisomerase II has also been shown to be a potential drug target. The enzyme has been shown to play a role in a number of diseases, including cancer, and has been shown to be involved in the regulation of cellular processes that are important for disease progression. In addition, the study of DNA topoisomerase II has also identified a number of potential biomarkers for disease diagnosis and treatment.

In conclusion, DNA topoisomerase II is a protein that plays a crucial role in the process of DNA replication in eukaryotic cells. It is a topoisomerase, which means it helps to unwind double-stranded DNA and create two complementary copies of the same strand. In In addition to its role in DNA replication, DNA topoisomerase II is also involved in the regulation of gene expression and has been implicated in a number of cellular processes, including cell division, differentiation, and the response to environmental stimuli. The enzyme has a unique structure that allows it to efficiently bind to DNA and has been shown to play a role in the regulation of DNA-protein interactions and in the regulation of DNA replication. DNA topoisomerase II is a potential drug target and has been shown to be involved in a number of diseases, including cancer. In addition, the study of DNA topoisomerase II has also identified a number of potential biomarkers for disease diagnosis and treatment.

Protein Name: DNA Topoisomerase II (nonspecified Subtype)

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